Vasculitis & polymyalgia rheumatica
Validation of the 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis
Authors' conclusion
The poor specificity of the 2022 ACR/EULAR TAK criteria in real-life settings was improved by increasing the cut-off to 6 or 7, or removing the point for female sex.
Study context
- Population
- Patients with TAK vs controls (extracranial giant cell arteritis (EC-GCA) and other controls) from four referral centres504 TAK, 222 controls
- Comparison
- 2022 ACR/EULAR TAK classification criteria vs 1990 ACR TAK classification criteria
- Outcome
- Classification performance at pre-determined cut-offs (TAK vs all controls)
Methodological detailsmulticentre (four referral centres), classification criteria validation
- Multicentre (four referral centres)
- Classification criteria validation
Performance
As reported in the abstract
| Test or model | Sensitivity | Specificity |
|---|---|---|
| 2022 ACR/EULAR criteria | 95.83% | 63.51% |
| 1990 ACR criteria | 82.94% | 90.54% |
Sensitivity
2022 ACR/EULAR criteria95.83%
1990 ACR criteria82.94%
Specificity
2022 ACR/EULAR criteria63.51%
1990 ACR criteria90.54%
Further findings
- 2022 ACR/EULAR criteria with only EC-GCA as controls
- 95.83% · sensitivity · specificity 60.42% · AUC 0.781
2022 ACR/EULAR criteria by sex (males vs females)
- Specificity, males vs females
- 76.06% vs 57.62%
- AUC, males vs females
- 0.845 vs 0.771
- Sensitivity, males vs females (similar)
- 93% vs 96.53%
2022 ACR/EULAR criteria by age (40-60 years vs <40 years)
- Sensitivity remained similar, whereas specificity was higher for 40-60 years vs <40 years
2022 ACR/EULAR criteria, alternative cut-offs and scoring
- Cut-off ≥6: sensitivity
- 91.87%
- Cut-off ≥6: specificity
- 82.88%
- Cut-off ≥7: sensitivity
- 86.71%
- Cut-off ≥7: specificity
- 86.49%
- Removing the point for female sex: sensitivity
- 92.64%
- Removing the point for female sex: specificity
- 81.08%
Original publication
Validation of the 2022 American College of Rheumatology/EULAR classification criteria for Takayasu arteritis. Rheumatology (Oxford). Published 5 April 2023. doi:10.
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