Vasculitis & polymyalgia rheumatica
Prevalence and distribution of vascular calcifications at CT scan in patients with and without large vessel vasculitis: a matched cross-sectional study
Main finding · Thoracic artery calcificationsResult — go to the resultOdds ratio 4.13 95% CI 1.35–12.66Authors' conclusion
When compared with patients without LVVs, LVVs patients have higher calcifications in the thoracic arteries, but not in coronary and abdominal arteries.
Study context
- Population
- Patients with large vessel vasculitis (LVV) and matched lymphoma patients with baseline positron emission tomography-CT (PET-CT) performed between 2007 and 2019
- Participants
- 266 patients
- Exposure
- LVV vs lymphoma patients
- Outcome
- Prevalence, entity and local distribution of arterial wall calcifications on CT (coronaries, thoracic and abdominal arteries), quantified as Agatston and volume scores
- Follow-up
- Baseline
Methodological detailsmatched by age (±5 years), sex and year of baseline PET-CT, retrospective, single radiologist
- Matched by age (±5 years), sex and year of baseline PET-CT
- Retrospective
- Single radiologist
Main finding
Thoracic artery calcifications
Odds ratio
4.13
95% CI 1.35–12.66
P = 0.013
LVVsvs Lymphomas
OR 4.13 (95% CI 1.35–12.66); P = 0.013
As reported in the abstract
Observational data: associations, not effects.
Further findings
Mean
| Outcome | LVVs | Lymphomas |
|---|---|---|
| Abdominal artery calcifications, volume | 3220 | 2712 |
- Coronary calcifications, volume (patients >50 years old, subgroup) · more extended in non-LVV patients
- P = 0.027 for volume
Abdominal artery calcifications, volume
- Equally distributed
Original publication
Prevalence and distribution of vascular calcifications at CT scan in patients with and without large vessel vasculitis: a matched cross-sectional study. RMD Open. Published 28 August 2023. doi:10.
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