Vasculitis & polymyalgia rheumatica
Association of 18F‐Fluorodeoxyglucose–Positron Emission Tomography Activity With Angiographic Progression of Disease in Large Vessel Vasculitis
Main finding · Angiographic changeResult — go to the resultOdds ratio 19.49 95% CI 2.44–156.02Authors' conclusion
Development of angiographic change was infrequent in this cohort of patients with LVV. A lack of baseline FDG-PET activity was strongly associated with stable angiographic disease. In cases of angiographic progression, change was preceded by the presence of FDG-PET activity.
Study context
- Population
- Patients with large vessel vasculitis (LVV) (TAK and GCA) undergoing MR or CT angiography and FDG-PET, with follow-up imaging ≥6 months later
- Participants
- 1,091 arterial territories
- Exposure
- Arterial territories with vs without baseline FDG-PET activity
- Baseline FDG-PET activityn = 298
- No baseline FDG-PET activityn = 793reference
- Outcome
- Angiographic change (new lesions, improved or worsened existing lesions) in 17 arterial territories
- Follow-up
- Median 1.6 years
Methodological detailsstandardized imaging protocol, paired within-patient analysis
- Standardized imaging protocol
- Paired within-patient analysis
Main finding
Angiographic change
Odds ratio
19.49
95% CI 2.44–156.02
P < 0.01
Events by group
Baseline FDG-PET activity
8%
24 of 298
No baseline FDG-PET activity
6
events
Baseline FDG-PET activityvs No baseline FDG-PET activity
OR 19.49 (95% CI 2.44–156.02); P < 0.01
As reported in the abstract
- Of territories that developed angiographic change, proportion with baseline FDG-PET activity
- 80%
Observational data: associations, not effects.
Further findings
New lesions · median 1.6 years
- New lesions developed only in arterial territories of patients with TAK
- 8 arterial territories in 5 patients
Change in existing arterial lesions · median 1.6 years
- Improved
- 16 territories
- Worsened
- 6 territories
Original publication
Association of 18F‐Fluorodeoxyglucose–Positron Emission Tomography Activity With Angiographic Progression of Disease in Large Vessel Vasculitis. Arthritis Rheumatol. Published 8 December 2022. doi:10.
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