Vasculitis & polymyalgia rheumatica
Cardiovascular diseases and their associations with lipid parameters and endothelial dysfunction in giant cell arteritis
Authors' conclusion
GCA patients are at a high risk of developing cardiovascular diseases. Of relevance, there was underuse of statins and a large proportion of these patients showed LDL cholesterol concentrations above the treatment targets for high-risk patients.
Study context
- Population
- Patients with giant cell arteritis (GCA) and controls evaluated in 2012, follow-up by chart review in 2020
- Participants
- 138 vs 100
- Exposure
- GCA patients vs controls
- GCAn = 138
- Controlsn = 100reference
- Outcome
- Prevalence and development of CVD; endothelial dysfunction and lipid metabolism
Methodological detailscontrolled, chart review follow-up to 2020
- Controlled
- Chart review follow-up to 2020
Main finding
As reported in the abstract
- Prevalent carotid and vertebral artery disease higher in GCA than controls
- p<0.001
- GCA had higher total cholesterol, low-density lipoprotein (LDL), intermediate-density lipoprotein, HDL, apolipoprotein A1 and B, and augmentation index
- all with p<0.05
- Target LDL levels less frequently achieved at inclusion by GCA
- p=0.001
- GCA developed new CV events more frequently, also with a higher amount, during follow-up
- all with p<0.001
Observational data: associations, not effects.
Further findings
Relapse and future CV events (GCA)
| OR (95% CI) | P value | ||
|---|---|---|---|
| RelapseIndependently associated | 5.01 (1.55–16.22) | P = 0.007 | |
| 0.050.21520Odds ratio (log scale) |
Statin treatment in GCA and asymmetric dimethylarginine, monocytes and CRP
- Statin treatment associated with lower asymmetric dimethylarginine, monocytes and CRP
- all with p<0.05
Original publication
Cardiovascular diseases and their associations with lipid parameters and endothelial dysfunction in giant cell arteritis. RMD Open. Published 1 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →