Sjögren's disease & overlap diseases
Kynurenines and neopterin are interferon-gamma-inducible biomarkers for Sjögren’s disease
Authors' conclusion
Kynurenines and neopterin are interferon-gamma-inducible biomarkers associated with more chances for SjD and with disease activity, glandular dysfunction, autoantibodies and immunological and inflammatory biomarkers.
Study context
- Population
- Sjögren's disease (SjD) patients and age- and sex-matched healthy volunteers
- Participants
- 97 vs 63
- Comparison
- SjD patients vs age- and sex-matched healthy volunteers
- SjDn = 97
- Healthy volunteersn = 63reference
- Outcome
- Whether kynurenine pathway metabolites and neopterin increase probability for SjD
Methodological detailsage- and sex-matched healthy volunteers
- Age- and sex-matched healthy volunteers
Main finding
As reported in the abstract
Kynurenine pathway metabolites, neopterin and probability of SjD
Each group vs healthy volunteersEstimate (95% CI)
SjD
OR (kynurenine) 2.51(1.44–5.64)
SjD
OR (KTR) 3.45(1.76–6.74)
SjD
OR (neopterin) 4.28(1.95–9.42)
SjD
OR (vitamin B6 metabolite PAr) 3.34(1.19–9.39)
- Tryptophan lower in SjD
- P = 0.012
- Kynurenine higher in SjD
- P = 0.005
- Kynurenine/tryptophan ratio (KTR) higher in SjD
- P = 0.001
- Neopterin higher in SjD
- P = 0.02
Observational data: associations, not effects.
Further findings
Associations with clinical parameters
- Kynurenine, KTR, neopterin and PAr associated with disease activity, longer disease duration, depression, impaired salivary flow, hypergammaglobulinemia, neutropenia, hypocomplementemia and positive anti-Ro/SSA and anti-La/SSB
Associations with inflammatory biomarkers
- Neopterin correlated with kynurenines; both associated with PAr and pro-inflammatory cytokines, mainly TNF-α, IL-1β and TNF receptors I and II
Original publication
Kynurenines and neopterin are interferon-gamma-inducible biomarkers for Sjögren’s disease. Rheumatology (Oxford). Published 25 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →