Sjögren's disease & overlap diseases
Arterial cardiovascular outcomes and venous thromboembolism in patients with primary Sjögren’s syndrome: a Danish cohort study
Authors' conclusion
This study provides firm evidence that pSS is associated with increased risk of all atherosclerotic cardiovascular outcomes and venous thromboembolism
Study context
- Population
- Patients with pSS in Denmark, 1996–2017 (median age 57 years, 87% women), and a matched general-population cohortmedian follow-up 7.6 years
- Participants
- 4,697 vs 46,970
- Exposure
- pSS vs matched comparison cohort from the general population
- pSSn = 4,697
- Comparisonn = 46,970reference
- Outcome
- Atherosclerotic CVD outcomes, VTE, HF and cardiovascular mortality (hospital contact diagnoses)
Methodological detailsmatched on age, gender and calendar year, Cox regression, adjusted for potential confounders
- Matched on age, gender and calendar year
- Cox regression, adjusted for potential confounders
Main finding
As reported in the abstract
Arterial cardiovascular outcomes, VTE, HF and cardiovascular death
pSS vs ComparisonAdjusted hazard ratio (95% CI)
MI
1.23(1.01–1.50)
Ischaemic stroke
1.31(1.14–1.52)
Haemorrhagic stroke
1.51(1.13–2.03)
Peripheral artery disease
1.44(1.13–1.83)
VTE
1.57(1.33–1.85)
Cardiovascular death (slightly elevated)
1.11(0.95–1.30)
HF (slightly elevated)
1.17(0.99–1.39)
Observational data: associations, not effects.
Original publication
Arterial cardiovascular outcomes and venous thromboembolism in patients with primary Sjögren’s syndrome: a Danish cohort study. Rheumatology (Oxford). Published 23 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →