Sjögren's disease & overlap diseases
Clinical stratification of 1318 Primary Sjögren's Syndrome patients
Authors' conclusion
In this cohort study, we summarized the clinical characteristics of Chinese patients with pSS and identified four distinct subgroups of pSS based on systemic involvement, revealing clinical and molecular disparities that unveil distinct pathobiological endotypes.
Study context
- Population
- Chinese patients with Primary Sjögren's Syndrome (pSS)
- Participants
- 1,318 patients
- Exposure
- pSS subtypes (C1–C4) identified by unsupervised clustering on systemic involvement; comparisons by gender, anti-SSA antibodies and LGSB
- Outcome
- pSS subtypes based on systemic involvement
Methodological detailsobservational, unsupervised clustering analysis
- Observational
- Unsupervised clustering analysis
Main finding
As reported in the abstract
- pSS patients categorized into four groups based on systemic involvement
- C1: lowest ESSDAI scores; C4: highest ESSDAI scores
- Positivity rates of antibodies, immunological parameters and inflammatory markers differed significantly among the groups
- Notable variances in expression of peripheral blood transcriptomic modules among groups
Observational data: associations, not effects.
Further findings
Extraglandular manifestations by gender, anti-SSA and LGSB
- More pronounced extraglandular manifestations among male patients, SSA-negative group, and those with positive LGSB results
Original publication
Clinical stratification of 1318 Primary Sjögren's Syndrome patients. Semin Arthritis Rheum. Published 10 August 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →