Sjögren's disease & overlap diseases
Mitochondrial dysfunction and fatigue in Sjögren’s disease
Authors' conclusion
Mitochondrial dysfunction and fatigue are significant problems in SjD warranting further investigation.
Study context
- Population
- Sjögren's disease (SjD) and non-Sjögren's sicca (NSS) subjects completing fatigue questionnaires, and healthy subjects; pan T cells from PBMCs
- Participants
- 13 / 4 / 8
- Comparison
- SjD and NSS vs healthy subjects
- SjDn = 13
- NSSn = 4
- Healthyn = 8reference
- Outcome
- Mitochondrial dysregulation in T cells (Seahorse OCR and extracellular acidification rate) and its association with fatigue
Methodological detailsSeahorse metabolic analysis, public microarray data analysis
- Seahorse metabolic analysis
- Public microarray data analysis
Main finding
As reported in the abstract
T-cell mitochondrial respiration (Seahorse)
- Basal oxygen consumption rate (OCR), ATP-linked respiration, maximal respiration and reserve capacity significantly lower in SjD and NSS vs healthy
- No differences in non-mitochondrial respiration, basal glycolysis or glycolytic reserve
- Sleep questionnaire and Bowman's Profile of Fatigue and Discomfort scores correlated with altered OCR in SjD
Observational data: associations, not effects.
Further findings
Mitophagic transcriptional signature in public microarray data (190 SjD, 32 healthy)
- Signature stratified SjD patients into discrete clusters
- 5
- Subgroup differential expression analysis expanded number of differentially expressed transcripts
- tenfold
Original publication
Mitochondrial dysfunction and fatigue in Sjögren’s disease. RMD Open. Published 23 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →