Lupus & antiphospholipid syndrome
Incidence and risk of arterial and venous thrombotic events in systemic lupus erythematosus patients: a population-based study
Main finding · ATE, incidence rate per 1000 PY and adjusted HRResult — go to the resultHazard ratio 1.65 95% CI 1.20–2.26Authors' conclusion
Our findings confirmed higher risks of ATE, VTE and all-cause death in SLE patients.
Study context
- Population
- Incident systemic lupus erythematosus (SLE) cases 2010–2019, administrative health databases of the Lombardy Region, Italy
- Participants
- 2,133 vs 21,283
- Exposure
- Incident SLE vs age- and sex-matched controls without SLE
- SLEn = 2,133
- No-SLEn = 21,283reference
- Outcome
- Incidence and risk of arterial and venous thrombotic events (ATE and VTE) and all-cause death
Methodological detailsadministrative health databases, age- and sex-matched controls
- Administrative health databases
- Age- and sex-matched controls
Main finding
ATE, incidence rate per 1000 PY and adjusted HR
Hazard ratio
1.65
95% CI 1.20–2.26
P < 0.0001
By group
SLEvs No-SLE
HR 1.65 (95% CI 1.20–2.26); P < 0.0001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Incidence rate, per 1000 person-years (PY)
| Outcome | SLE | No-SLE | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| VTE, incidence rate per 1000 PY and adjusted HRAdjusted HR; P for incidence rate comparison | 1.85 | 0.67 | 2.25 (1.35–3.74) | P < 0.0001 | |
| All-cause death, incidence rate per 1000 PY and adjusted HRAdjusted HR; P for incidence rate comparison | 15.18 | 6.22 | 1.81 (1.52–2.15) | P < 0.0001 | |
| 0.20.5125Hazard ratio (log scale) |
Pharmacotherapy after SLE diagnosis
- HCQ and GC prescribed for at least 60% of SLE patients
- Higher exposure to cardiovascular (CV) medications in SLE patients
Original publication
Incidence and risk of arterial and venous thrombotic events in systemic lupus erythematosus patients: a population-based study. Rheumatology (Oxford). Published 14 September 2024. doi:10.
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