High prevalence of sacroiliitis and early structural changes in the sacroiliac joint in children with enthesitis-related arthritis: findings from a tertiary centre in Hong Kong
Authors' conclusion
We found that a high proportion of ERA patients had sacroiliitis and a significant number of them had radiological structural changes during early disease.
Study context
- Population
- Children with juvenile idiopathic arthritis (JIA) attending the paediatric rheumatology clinic, Prince of Wales Hospital, Hong Kong, January 1990 to December 2020
- Participants
- 101 children
- Exposure
- Enthesitis-related arthritis (ERA) with sacroiliac joint (SIJ) structural changes vs ERA without SIJ structural changes
- Outcome
- Clinical course and radiological findings of the SIJ among ERA patients
Methodological detailssingle-centre, tertiary centre registry
- Single-centre
- Tertiary centre registry
Main finding
As reported in the abstract
Radiological SIJ findings among ERA patients
- Radiological evidence of sacroiliitis
- 78%
- Bilateral involvement among those with sacroiliitis
- 81%
- Median duration from disease onset to radiological sacroiliitis, months (IQR 4-62)
- 17
- Structural changes of the SIJ
- 73%
- Structural changes already present when sacroiliitis first detected on imaging (IQR 0-12 months)
- 70%
- Erosion
- 73%
- Sclerosis
- 63%
- Joint space narrowing
- 23%
- Ankylosis
- 7%
- Fatty change
- 3%
Observational data: associations, not effects.
Further findings
Duration from symptom onset to diagnosis, ERA with vs without SIJ structural changes · significantly longer with structural changes
P = 0.009
JIA subtype prevalence
- ERA (most prevalent subtype)
- 40%
- Oligoarticular JIA
- 17%
- Median age at diagnosis 11 years (IQR 8-15); median follow-up 7 years (IQR 2-11.5)
Original publication
High prevalence of sacroiliitis and early structural changes in the sacroiliac joint in children with enthesitis-related arthritis: findings from a tertiary centre in Hong Kong. Pediatr Rheumatol Online J. Published 3 May 2023. doi:10.
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