Natural autoimmunity in oligoarticular juvenile idiopathic arthritis
Authors' conclusion
Our findings are in accordance with the hypothesis that NAbs contribute to the pathogenesis of autoimmune diseases and provide additional evidence that disturbances in natural autoimmunity may contribute to the as yet unclarified pathogenesis of oligo-JIA.
Study context
- Population
- Children with persistent oligoarticular JIA and healthy matched controls
- Participants
- 70 vs 20
- Comparison
- Children with persistent oligo-JIA vs healthy matched controls
- Oligo-JIAn = 70
- Healthy controlsn = 20reference
- Outcome
- Serum IgM and IgA natural antibodies (anti-TNP, anti-actin, anti-F(ab΄)2) measured by in-house enzyme-immunoassays
Methodological detailshealthy matched controls, backward regression analysis
- Healthy matched controls
- Backward regression analysis
Main finding
As reported in the abstract
- Ratios of IgA anti-TNP, anti-actin and anti-F(ab΄)2 levels to total serum IgA significantly increased in oligo-JIA vs healthy subjects
- IgM anti-TNP significantly elevated in inactive oligo-JIA vs active disease and vs healthy controls
- IgM anti-TNP significantly higher with anterior uveitis than without uveitis or in healthy controls
- Disease activity and anterior uveitis independently affect IgM anti-TNP levels (backward regression)
Observational data: associations, not effects.
Original publication
Natural autoimmunity in oligoarticular juvenile idiopathic arthritis. Pediatr Rheumatol Online J. Published 3 May 2023. doi:10.
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