Lupus & antiphospholipid syndrome
Fluid Cognition Among Individuals With Systemic Lupus Erythematosus
Authors' conclusion
Fluid cognition and, particularly, attention and inhibitory control were low in those with SLE relative to the general US population. Working status, higher physical functioning and performance, and higher educational attainment were associated with lower prevalence of potential impairment.
Study context
- Population
- Individuals with systemic lupus erythematosus (SLE) from a population-based cohort (mean age 46.1 years; 87.4% female; 86.4% Black)
- Participants
- 199 individuals
- Outcome
- Fluid cognition (NIH Toolbox Fluid Cognition Battery, age-corrected standard scores, mean 100, SD 15); potential impairment = score >1.5 SD below the mean
Methodological detailspopulation-based cohort, single study visit, multivariable logistic regression, Single study visit, October 2019 to May 2022
- Population-based cohort
- Single study visit
- Multivariable logistic regression
- Single study visit, October 2019 to May 2022
Main finding
As reported in the abstract
Fluid cognition, age-corrected standard score
Mean overall fluid cognition score
87.2
Lowest domain: attention and inhibitory control, mean score
82.0
Observational data: associations, not effects.
Further findings
Associations with potential fluid cognition impairment (multivariable logistic regression)
| OR (95% CI) | ||
|---|---|---|
| Working statusLower odds of impairment | 0.30 (0.14–0.64) | |
| Higher self-reported physical functioningLower odds of impairment | 0.46 (0.28–0.75) | |
| Higher physical performanceLower odds of impairment | 0.72 (0.59–0.87) | |
| Lower educational attainmentHigher odds of impairment | 3.82 (1.67–8.75) | |
| 0.10.31310Odds ratio (log scale) |
- Self-reported forgetfulness, neuropsychiatric damage and depressive symptoms not statistically significantly associated with potential impairment
Original publication
Fluid Cognition Among Individuals With Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 2 May 2024. doi:10.
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