Spondyloarthritis & psoriatic arthritis
Dysregulation of Bile Acids, Lipids, and Nucleotides in Psoriatic Arthritis Revealed by Unbiased Profiling of Serum Metabolites
Authors' conclusion
We observed notable differences in bile acid, purine, lipid, and amino acid-derived metabolites, among the healthy controls, psoriasis patients, and PsA patients and identified changes during the transition from psoriasis to PsA.
Study context
- Population
- Healthy controls, psoriasis patients and psoriatic arthritis (PsA) patients
- Comparison
- PsA vs psoriasis vs healthy controls; psoriasis progressing vs not progressing to PsA
- Outcome
- Serum metabolic alterations during progression of arthritis in psoriasis patients
Methodological detailscross-sectional and longitudinal, nontargeted metabolomic profiling (liquid chromatography mass spectrometry)
- Cross-sectional and longitudinal
- Nontargeted metabolomic profiling (liquid chromatography mass spectrometry)
Main finding
As reported in the abstract
- Differentially abundant bile acids, purines, pyrimidines, glutathione, lipids and amino acid metabolites among PsA, psoriasis and healthy controls
- Bile acid and butyrate levels depressed in those who progressed to PsA vs those who did not
- Inflammatory lipid mediators increased following PsA diagnosis
- Combination of leukotriene B4 and glycoursodeoxycholic acid sulfate were sensitive and specific predictors of PsA progression
Original publication
Dysregulation of Bile Acids, Lipids, and Nucleotides in Psoriatic Arthritis Revealed by Unbiased Profiling of Serum Metabolites. Arthritis Rheumatol. Published 25 November 2022. doi:10.
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