Spondyloarthritis & psoriatic arthritis
Individual Regression Modeling of Spinal Mobility Measurements in Long‐Term Ankylosing Spondylitis: In‐Depth Analyses With Comparison to Norm Data
Authors' conclusion
Based on median constants of our data, mobility restrictions related to AS seem to mainly occur during the first years of disease
Study context
- Population
- Patients with long-term ankylosing spondylitis (AS) (median age 20.9 years at symptom onset), followed for a median of 34 years since symptom onset111 men and 30 women
- Exposure
- Spinal mobility decline in AS vs age-related norm data
- Outcome
- Linearity of spinal mobility deterioration (LSF, ST10, CE, CR) vs normal age-related decline
Methodological detailsindividual linear regression modelling, comparison with age-related norm data, 9,697 spinal mobility measurements analysed
- Individual linear regression modelling
- Comparison with age-related norm data
- 9,697 spinal mobility measurements analysed
Main finding
As reported in the abstract
Yearly linear decline in spinal mobility (individual regression beta)
AS
−0.62°
median · IQR −1.16–-0.22
Norm data
−0.35°
median · IQR −0.35–-0.35
Observational data: associations, not effects.
Further findings
Temporary fluctuations in lateral spinal flexion (LSF) and chest expansion (CE)
- Significantly higher during the early phase of the disease, with decreasing residuals over time
Original publication
Individual Regression Modeling of Spinal Mobility Measurements in Long‐Term Ankylosing Spondylitis: In‐Depth Analyses With Comparison to Norm Data. Arthritis Care Res (Hoboken). Published 18 November 2022. doi:10.
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