Spondyloarthritis & psoriatic arthritis
Systematic review and meta-analysis of individual serum lipids and analysis of lipid ratios in ankylosing spondylitis and healthy control cohorts: significantly lower mean HDL-cholesterol level in ankylosing spondylitis cohorts
Pooled result · HDL-CResult — go to the resultPooled Hedges' g −0.484 95% CI −0.664 to −0.305Authors' conclusion
Highly significantly lower HDL-C levels occurred in AS versus HC subjects.
Study context
- Population
- Ankylosing spondylitis (AS) and healthy control cohorts; English-language articles in PubMed, Ovid Medline, Embase and Scopus, 1970 to 202168 articles
- Comparison
- AS vs healthy controls
- Outcome
- Serum lipids and lipoprotein ratios (SMD) in AS vs HC
Methodological detailsrandom-effects model, SMD (Hedges' g)
- Random-effects model
- SMD (Hedges' g)
Pooled result
HDL-C
Pooled Hedges' g
−0.484
95% CI −0.664 to −0.305
P < 0.001
ASvs HC
pooled Hedges' g −0.484 (95% CI −0.664 to −0.305); P < 0.001
As reported in the abstract
Further pooled results
Total ÷ HDL-C ratio (AS minus healthy control (HC) weighted means)
- HC values below the lowest ratio in AS
- 8
Original publication
Systematic review and meta-analysis of individual serum lipids and analysis of lipid ratios in ankylosing spondylitis and healthy control cohorts: significantly lower mean HDL-cholesterol level in ankylosing spondylitis cohorts. Clin Exp Rheumatol. Published 30 November 2022. doi:10.
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