Spondyloarthritis & psoriatic arthritis
Utility of nailfold capillary assessment for predicting psoriatic arthritis based on a prospective observational cohort study
Authors' conclusion
NFC abnormalities were suggested to be a predictor of PsA in psoriasis patients, and at the same time, its degree could be an indicator of disease severity.
Study context
- Population
- Psoriasis patients not treated with systemic therapy or topical finger therapy
- Participants
- 449 participants
- Exposure
- Nailfold capillary (NFC) abnormalities as predictors of PsA in psoriasis
- Psoriasis vulgaris (PsV)n = 236reference
- PsAn = 213
- Outcome
- Incidence of new PsA by NFC abnormalities (NFB and enlarged capillaries)
Methodological detailsobservational, multivariate analysis
- Observational
- Multivariate analysis
Main finding
As reported in the abstract
Predictors of PsA development in PsV patients (multivariate analysis) · mean 21 months (95% CI 2, 77 months) before PsA development
Hazard ratio (95% CI)
NFB
2.75(1.38–5.47)
Enlarged capillaries
4.49(2.25–8.96)
Observational data: associations, not effects.
Further findings
NFB frequency at inclusion
P < 0.0001
Enlarged capillaries frequency at inclusion
P < 0.0001
Degree of NFC abnormalities vs PsA severity and serum cytokines
- Degree of NFC abnormalities correlated with PsA severity and serum cytokine levels
Original publication
Utility of nailfold capillary assessment for predicting psoriatic arthritis based on a prospective observational cohort study. Rheumatology (Oxford). Published 28 November 2022. doi:10.
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