Spondyloarthritis & psoriatic arthritis
Association of ankylosing spondylitis with the risk of cancer: a meta-analysis of cohort studies
Pooled result · Overall cancerResult — go to the resultRelative risk 1.16 95% CI 1.07–1.26Authors' conclusion
AS appears to be related to cancer development.
Study context
- Population
- Cohort studies of ankylosing spondylitis (AS) and cancer risk (PubMed, EMBASE, Cochrane Library up to 10 July 2023)
- Participants
- >330,000 participants20 cohorts
- Comparison
- AS vs no AS
- Outcome
- Cancer risk (RR)
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
Overall cancer
Relative risk
1.16
95% CI 1.07–1.26
P = 0.001
ASvs Non-AS
RR 1.16 (95% CI 1.07–1.26); P = 0.001
As reported in the abstract
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Bone cancerI2 = 0.00% | 3.41 (1.45–7.99) | P = 0.005 | |
| Thyroid gland cancerI2 = 13.70% | 1.76 (1.29–2.40) | P < 0.001 | |
| Multiple myelomaI2 = 27.20% | 1.74 (1.42–2.15) | P < 0.001 | |
| LeukaemiaI2 = 0.00% | 1.52 (1.27–1.82) | P < 0.001 | |
| Kidney cancerI2 = 0.00% | 1.45 (1.08–1.94) | P = 0.014 | |
| Prostate cancerI2 = 82.80% | 1.43 (1.17–1.74) | P < 0.001 | |
| Non-Hodgkin's lymphomaI2 = 0.00% | 1.42 (1.17–1.73) | P < 0.001 | |
| 0.10.31310Relative risk (log scale) |
Overall cancer by region (subgroup)
- Higher cancer risk with AS in Asia; association not significant in Europe
Other cancer types
- No significant correlation with connective tissue, brain, testicular and other male, bladder, female, skin, digestive and respiratory system cancers
Original publication
Association of ankylosing spondylitis with the risk of cancer: a meta-analysis of cohort studies. Rheumatology (Oxford). Published 3 June 2024. doi:10.
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