Spondyloarthritis & psoriatic arthritis
Musculoskeletal Surgery in Psoriatic Arthritis: Prevalence and Risk Factors
Authors' conclusion
MSK surgery attributable to PsA is not rare, affecting 11.8% of patients. Markers of cumulative disease activity and damage are associated with a greater risk of requiring surgery.
Study context
- Population
- Patients with PsA fulfilling Classification Criteria for Psoriatic Arthritis, single-centre cohort, January 1978 to December 2019
- Participants
- 1,574 patients
- Outcome
- Prevalence and types of MSK surgery attributable to PsA; risk factors for first MSK surgery attributable to PsA
Methodological detailssingle-centre, Cox proportional hazards models with time-dependent covariates, 1-to-1 matching on markers of PsA disease severity (biologics analysis)
- Single-centre
- Cox proportional hazards models with time-dependent covariates
- 1-to-1 matching on markers of PsA disease severity (biologics analysis)
Main finding
As reported in the abstract
MSK surgery attributable to PsA
- Patients with musculoskeletal (MSK) surgery related to PsA
- 185
- MSK surgeries related to PsA
- 379
- Patients affected
- 11.8%
- Risk factor (multivariate): total number of damaged joints, HR
- 1.03, P < 0.001
- Risk factor (multivariate): tender/swollen joints, HR
- 1.04, P = 0.01
- Risk factor (multivariate): presence of nail lesions, HR
- 2.08, P < 0.01
- Risk factor (multivariate): higher HAQ scores, HR
- 2.01, P < 0.001
- Risk factor (multivariate): elevated ESR, HR
- 2.37, P = 0.02
- Risk factor (multivariate): HLA-B27 positivity, HR
- 2.22, P = 0.048
- Protective (multivariate): higher PASI, HR
- 0.88, P < 0.002
Observational data: associations, not effects.
Further findings
Effect of biologics on time to first MSK surgery (1-to-1 matched dataset)
- The effect of biologics did not reach statistical significance
Original publication
Musculoskeletal Surgery in Psoriatic Arthritis: Prevalence and Risk Factors. J Rheumatol. Published 15 November 2022. doi:10.
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