Spondyloarthritis & psoriatic arthritis
Evaluation of Standard and Proposed Reference Values for Entheseal Thickening by Using Musculoskeletal Ultrasound
Authors' conclusion
Although using cut-offs appears to be an appealing method to evaluate entheseal thickness, the measurements may be affected by several confounding factors, leading to a low discriminative value, except for at the triceps tendon enthesis.
Study context
- Population
- Healthy controls (HCs) and patients with axial spondyloarthritis (axSpA) undergoing ultrasound (US) of entheses2,160 entheses
- Participants
- 80 vs 100
- Comparison
- Current literature cut-offs vs proposed cut-offs (mean ± 2 SD) for US entheseal thickening
- HCsn = 80reference
- axSpAn = 100
- Outcome
- Frequency of entheseal thickening on US using existing cut-off values
Methodological detailscase-control (HCs vs axSpA)
- Case-control (HCs vs axSpA)
Performance
As reported in the abstract
Entheseal thickening by current cut-offs (% of entheses)
Further findings
Entheseal thickening by proposed cut-offs (mean ± 2 SD)
- Proposed cut-offs decreased frequency of thickening in both groups, increasing specificity at the cost of decreasing sensitivity
Discrimination of disease from health by thickness at the triceps tendon enthesis (the only anatomical site with discriminative value)
- OR, current cut-offs
- 13.4 (95% CI 4.0-44.8)
- OR, proposed cut-offs
- 10.3 (95% CI 4.0-26.6)
Original publication
Evaluation of Standard and Proposed Reference Values for Entheseal Thickening by Using Musculoskeletal Ultrasound. J Rheumatol. Published 15 November 2022. doi:10.
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