Spondyloarthritis & psoriatic arthritis
Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen
Authors' conclusion
There is a strong site-specific association between pharyngeal culture samples and an increased risk of PsA and psoriasis, regardless of the pathogen.
Study context
- Population
- All samples sent for culture from a large population during a 3-year period, linked with nationwide registry data over 15 years313,235 bacterial cultures
- Participants
- 128,982 participants
- Exposure
- Pharyngeal cultures vs urine cultures
- Outcome
- Incident PsA and psoriasis (International Classification of Diseases (ICD) codes)
Methodological detailsregistry-linked, Cox proportional hazards models adjusted for age and gender
- Registry-linked
- Cox proportional hazards models adjusted for age and gender
Main finding
As reported in the abstract
Pharyngeal cultures vs Urine culturesHazard ratio (95% CI)
Incident PsA
8.78(3.23–23.91)
Incident psoriasis
8.00(5.28–12.12)
Observational data: associations, not effects.
Further findings
Pharynx vs nasopharynx and blood cultures
- Increased risk with pharyngeal cultures vs nasopharynx and blood cultures
Streptococci (any site)
- No association with streptococci, in the pharynx or any other site
Positive vs negative culture (any site)
- Positive bacterial culture associated with reduced risk of both PsA and psoriasis
Original publication
Strong site-specific association of pharyngeal cultures with the onset of psoriatic arthritis and psoriasis, regardless of pathogen. Rheumatology (Oxford). Published 23 April 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →