Spondyloarthritis & psoriatic arthritis
Both Disease Activity and HLA–B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients
Authors' conclusion
These findings reveal that genetic background and level of disease activity are likely to influence the composition of the gut microbiota of patients with SpA.
Study context
- Population
- Adult volunteers: Spondyloarthritis (SpA) patients and healthy controls
- Participants
- 102 vs 63
- Exposure
- SpA patients vs healthy controls
- SpAn = 102
- Healthy controlsn = 63reference
- Outcome
- Gut microbiota composition: species diversity, enterotypes, taxonomic and functional differences
Methodological detailsshotgun sequencing of fecal DNA, age-matched siblings of known HLA-B27 status among controls
- Shotgun sequencing of fecal DNA
- Age-matched siblings of known HLA-B27 status among controls
Main finding
As reported in the abstract
Gut microbiota composition
- Dysbiosis confirmed in SpA patients vs healthy controls
- Restricted microbiota diversity in patients with the most active disease
- Abundance of several bacterial species correlated with BASDAI score
- Significant differences in microbiota composition between HLA-B27-positive and HLA-B27-negative siblings of SpA patients
- Decreased abundance of several species in SpA, especially Clostridiales order
- Ruminococcus gnavus among top differentiating species with increased abundance in SpA
Observational data: associations, not effects.
Original publication
Both Disease Activity and HLA–B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients. Arthritis Rheumatol. Published 19 November 2022. doi:10.
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