Sjögren's disease & overlap diseases
Distinct immunological features characterize early-onset primary Sjögren’s disease
Authors' conclusion
This study characterizes the distinct peripheral immunological landscapes of early- and late-onset pSjD and identifies an immunological triad that may represent a unique 'immune endotype' for early-onset disease, offering insights into targeted monitoring and therapies.
Study context
- Population
- Newly diagnosed, untreated primary Sjögren's disease patients
- Participants
- 204 participants
- Exposure
- Early-onset vs late-onset primary Sjögren's disease (pSjD)
- Early-onsetn = 43
- Late-onsetn = 161reference
- Outcome
- Peripheral immune features, early- vs late-onset
Methodological detailsrandom forest and LASSO regression, forward stepwise logistic regression
- Random forest and LASSO regression
- Forward stepwise logistic regression
Main finding
As reported in the abstract
- Early-onset vs Late-onset: P = 0.005
- Early-onset vs Late-onset: P < 0.001
- Early-onset vs Late-onset: P = 0.006
- Early-onset vs Late-onset: P = 0.032
Observational data: associations, not effects.
Further findings
Independent factors for early-onset disease (logistic regression)
- NK cell counts, OR (P = 0.010)
- 0.993
- CD4+ T cell percentage, OR (P = 0.019)
- 0.947
- Th17/Treg cell ratios, OR (P = 0.029)
- 5.215
Original publication
Distinct immunological features characterize early-onset primary Sjögren’s disease. Rheumatology (Oxford). Published 23 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →