Sjögren's disease & overlap diseases
Juvenile Sjögren disease: time for age-specific classification criteria
Authors' conclusion
Recurrent parotitis and scarce sicca manifestations are two distinct clinical features of juvenile versus adult SjD.
Study context
- Population
- Patients diagnosed with juvenile Sjögren’s disease (SjD) over the past five years, single centre
- Participants
- 15 patients
- Exposure
- Primary SjD vs Secondary SjD
- Primary SjDn = Ten
- Secondary SjDn = five
- Outcome
- Clinical, laboratory and imaging manifestations of juvenile SjD
Methodological detailssingle-center, exploratory pilot
- Single-center
- Exploratory pilot
Main finding
As reported in the abstract
- Median age of disease onset, years (range 8.5-17.5)
- 11.5
- Median age at diagnosis, years (range 8.5-17.5)
- 12.5
- Musculoskeletal manifestations at onset, n
- 9
- Recurrent parotitis at onset, n
- 7
- Mucocutaneous manifestations at onset, n
- 6
- Cervical lymphadenopathy at onset, n
- 6
- Raynaud's phenomenon or acrocyanosis at onset, n
- 3
- Fever at onset, n
- 2
- Dysphagia at onset, n
- 2
- Respiratory symptoms at onset, n
- 2
- Sicca manifestations at onset, n
- 2
- Life-threatening macrophage activation syndrome (primary SjD), n
- 1
- Anti-SSA antibodies positive
- 13/15
- Abnormal large salivary gland US findings
- All patients
- US: heterogeneous echogenicity
- 14/15
- US: gland enlargement
- 14/15
- US: hyperemia
- 11/14
- US: cystic changes
- 10/15
- US: cervical lymphadenopathy
- 8/15
- US: intraductal mucus plugging or calcifications
- 3/15
- Small salivary gland biopsies negative for granulomas and malignancies, with lymphocytic sialoadenitis and focus score ≥1
- 13/13
Observational data: associations, not effects.
Original publication
Juvenile Sjögren disease: time for age-specific classification criteria. Pediatr Rheumatol Online J. Published 20 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →