Sjögren's disease & overlap diseases
Safety and procedural success of minor salivary gland biopsy in Sjögren's disease: a retrospective analysis of 202 patients
Authors' conclusion
MSGB with vertical incision technique has a very low frequency of serious and long-term complications with a success rate of 98%.
Study context
- Population
- Patients with suspected Sjögren's disease (SjD) who underwent minor salivary gland biopsy (MSGB) at an outpatient clinic, January 2014 to April 2024, with follow-up visitsof 257 undergoing MSGB
- Participants
- 202 patients
- Outcome
- AEs of MSGB using vertical incision technique
Methodological detailssingle-group, non-surgical setting, All biopsies performed by rheumatologists in a non-surgical setting
- Single-group
- Non-surgical setting
- All biopsies performed by rheumatologists in a non-surgical setting
Main finding
As reported in the abstract
AEs of MSGB
- Serious AE (local persistent paraesthesia)
- 1 (0.5%)
- Moderate adverse events (AEs) (one prolonged bleeding, one unclassified)
- 2 (1.0%)
- Mild AEs
- 18 (8.9%)
- Local discomfort after biopsy
- 32 (15.8%)
- AEs subsided during or up to 2 hours after biopsy
- 14 (6.9%)
- AEs subsided within three weeks
- 38 (18.8%)
Observational data: associations, not effects.
Further findings
Biopsies with insufficient material for histological analysis
- Biopsies not yielding sufficient material for histological analysis
- 4 (2%)
Safety
Serious AEs
- Serious AE (local persistent paraesthesia)
- 1 (0.5%)
Moderate AEs
- Moderate AEs (one prolonged bleeding, one unclassified event)
- 2 (1.0%)
Mild AEs
- Patients with mild AEs
- 18 (8.9%)
Local discomfort after biopsy
- Patients with local discomfort after biopsy
- 32 (15.8%)
Duration of AEs
- AEs subsided during or up to 2 hours after biopsy
- 14 (6.9%)
- AEs subsided within three weeks
- 38 (18.8%)
Original publication
Safety and procedural success of minor salivary gland biopsy in Sjögren's disease: a retrospective analysis of 202 patients. Clin Exp Rheumatol. Published 4 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →