Spondyloarthritis & psoriatic arthritis
CRP at diagnosis in psoriatic arthritis: what it means and associations with long-term outcomes
Authors' conclusion
Overall PsA characteristics are comparable, irrespective of the CRP levels at diagnosis, apart from new bone formation, enthesitis, 'persistent disease' and increased cardiometabolic burden, which were independently associated with elevated CRP levels at PsA diagnosis.
Study context
- Population
- Patients with PsA categorized by CRP at diagnosis
- Participants
- 609 patients
- Exposure
- Elevated vs normal CRP at PsA diagnosis
- Elevated CRPn = 477
- Normal CRPn = 132reference
- Outcome
- Features and long-term outcomes independently associated with elevated CRP at diagnosis (multivariable)
Methodological detailsreal-world study, multivariable logistic regression
- Real-world study
- Multivariable logistic regression
Main finding
As reported in the abstract
Elevated CRP vs Normal CRPOdds ratio (95% CI)
BMI of >25 kg/m²
1.69(1.05–2.72)
Enthesitis
2.04(1.24–3.38)
Hypertension
2.07(1.04–4.11)
New bone formation
2.57(1.33–4.94)
'persistent disease'
4.36(2.22–8.59)
Observational data: associations, not effects.
Further findings
Univariate associations with elevated CRP
- Elevated CRP associated with longer disease follow-up, BMI >25 kg/m², enthesitis (at diagnosis and during disease course), hypertension, hyperuricaemia, new bone formation and 'persistent disease'
- Univariate analysis
Original publication
CRP at diagnosis in psoriatic arthritis: what it means and associations with long-term outcomes. Rheumatology (Oxford). Published 7 August 2026. doi:10.
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