Spondyloarthritis & psoriatic arthritis
Influence of initial axial involvement on the phenotypic evolution of axial spondyloarthritis: 10-year data from the DESIR cohort
Main finding · Development of arthritisResult — go to the resultHazard ratio 1.61 95% CI 1.15–2.25Authors' conclusion
Diffuse initial axial involvement identifies a subgroup of patients with axSpA at increased risk of developing peripheral arthritis.
Study context
- Population
- Patients with axial spondyloarthritis (axSpA) at disease onset in the DESIR cohort with available data on initial location of inflammatory axial pain
- Participants
- 662 patients
- Exposure
- Initial location of inflammatory axial pain: cervicothoracic, lumbosacral or diffuse
- Cervicothoracicn = 94
- Lumbosacraln = 466reference
- Diffusen = 102
- Outcome
- Occurrence of extra-axial (arthritis, dactylitis, enthesitis) and extra-rheumatological manifestations (psoriasis, uveitis, inflammatory bowel disease)
- Follow-up
- 10 years
Methodological details10-year follow-up, multivariate Cox models adjusted for age, sex, csDMARD and bDMARD exposure (time-dependent) and baseline manifestations
- 10-year follow-up
- Multivariate Cox models adjusted for age, sex, csDMARD and bDMARD exposure (time-dependent) and baseline manifestations
Main finding
Development of arthritis
Hazard ratio
1.61
95% CI 1.15–2.25
Diffusevs Lumbosacral
HR 1.61 (95% CI 1.15–2.25)
As reported in the abstract
Observational data: associations, not effects.
Original publication
Influence of initial axial involvement on the phenotypic evolution of axial spondyloarthritis: 10-year data from the DESIR cohort. RMD Open. Published 5 August 2026. doi:10.
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