Spondyloarthritis & psoriatic arthritis
Gut inflammation is associated with structural spinal damage in axial spondyloarthritis – results from the observational SPARTAKUS cohort
Main finding · mSASSS above the median, all axSpAResult — go to the resultAdjusted odds ratio 2.2 95% CI 1.1–4.2Authors' conclusion
In the current study, the presence of gut inflammation, assessed by F-calprotectin, was cross-sectionally associated with more structural damage in the spine in patients with axSpA, even after adjustments for known risk factors for spinal damage.
Study context
- Population
- Patients with nr-axSpA or r-axSpA (ASAS or modified New York criteria) in a population-based cohort, southern Swedennr-axSpA/r-axSpA n = 76/152
- Exposure
- Elevated (≥ 50 mg/kg) vs normal F-calprotectin; normal/moderately/distinctly elevated F-calprotectin categories
- Outcome
- Structural spinal damage (mSASSS); mSASSS above the median
Methodological detailsobservational, one-way ANOVA, logistic regression adjusted for sex, symptom duration, HLA-B27 status, smoking, CRP, NSAID and anti-TNF therapy
- Observational
- One-way ANOVA
- Logistic regression adjusted for sex, symptom duration, HLA-B27 status, smoking, CRP, NSAID and anti-TNF therapy
Main finding
mSASSS above the median, all axial spondyloarthritis (axSpA)
Adjusted odds ratio
2.2
95% CI 1.1–4.2
Elevated F-calprotectin (≥ 50 mg/kg)vs Normal F-calprotectin
aOR 2.2 (95% CI 1.1–4.2)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (CI) | |
|---|---|---|
| mSASSS above the median, r-axSpA aloneElevated F-calprotectin (≥ 50 mg/kg)vs Normal F-calprotectin | 2.9 (1.2–7.1) | |
| 0.10.31310Adjusted odds ratio (log scale) |
mSASSS above the median, r-axSpA alone
- In r-axSpA, mSASSS distributions also differed significantly across F-calprotectin categories
Original publication
Gut inflammation is associated with structural spinal damage in axial spondyloarthritis – results from the observational SPARTAKUS cohort. Arthritis Res Ther. Published 21 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →