Spondyloarthritis & psoriatic arthritis
Impaired cardiorespiratory fitness in psoriatic arthritis: insights from cardiopulmonary exercise testing
Authors' conclusion
The CRF level of patients with PsA was significantly decreased compared to a physically active population with 41% having an impaired CRF.
Study context
- Population
- Patients with psoriatic arthritis (PsA) (41% females, mean age 51 years (SD=11))41% females
- Participants
- 80 patients
- Exposure
- PsA vs physically active reference population
- PsAn = 80
- Outcome
- CRF measured as VO2peak during incremental maximal cardiopulmonary exercise test, compared with reference charts of the general population
Methodological detailsincremental maximal cardiopulmonary exercise test, multivariable linear regression, Holm-Bonferroni correction
- Incremental maximal cardiopulmonary exercise test
- Multivariable linear regression
- Holm-Bonferroni correction
Main finding
As reported in the abstract
VO2peak
| Group | Value | % of physically active reference (mean) | Impaired cardiorespiratory fitness (CRF) |
|---|---|---|---|
| PsA | mean 26.03 (SD 7.56) mL/min/kg | 74.01% (SD=19.19) | 41% |
PsA
Valuemean 26.03 (SD 7.56) mL/min/kg
% of physically active reference (mean)74.01% (SD=19.19)
Impaired cardiorespiratory fitness (CRF)41%
- PsA vs Reference population: P < 0.001 — significantly decreased; one-sided t-test
Observational data: associations, not effects.
Further findings
Associations with VO2peak (log-transformed), multivariable linear regression adjusted for age and sex
- Disease activity (Psoriatic Arthritis Disease Activity Score), β
- −0.2757, p*=0.009
- Waist-hip ratio, β
- −0.4193, p*<0.001
- Patient-reported disease impact (Psoriatic Arthritis Impact of Disease 12-item questionnaire), β
- −0.2385, p*=0.015
- Moderate-to-vigorous physical activity during commuting and leisure time (minutes/week), β
- 0.1702, p*=0.015
- Adjusted R²
- 0.71
- P* = Holm-Bonferroni corrected
Original publication
Impaired cardiorespiratory fitness in psoriatic arthritis: insights from cardiopulmonary exercise testing. RMD Open. Published 20 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →