Consensus-Driven Definition for Unequivocal Sacroiliitis on Radiographs in Juvenile Spondyloarthritis
Authors' conclusion
This definition achieved excellent specificity and had higher AUROC and sensitivity values than the mNY criteria using both MRI reference standards.
Study context
- Population
- Juvenile patients with spondyloarthritis with a radiograph and magnetic resonance imaging (MRI) as part of a diagnostic evaluation for axial disease; median age 14.9 (range 6.7–20.1) years
- Participants
- 112 patients
- Comparison
- Consensus-derived unequivocal sacroiliitis criteria vs modified New York (mNY) criteria on pelvic radiographs, against MRI
- Outcome
- Diagnostic performance of radiographic sacroiliitis definitions vs MRI reference standards
Methodological detailsretrospective cohort, iterative expert consensus process, 2 MRI reference standards
- Retrospective cohort
- Iterative expert consensus process
- 2 MRI reference standards
Performance
As reported in the abstract
| Test or model | AUROC (first MRI reference standard) | AUROC (second MRI reference standard) | Sensitivity (first MRI reference standard) | Sensitivity (second MRI reference standard) | Specificity (both MRI reference standards) |
|---|---|---|---|---|---|
| Unequivocal sacroiliitis criteria | 0.76 | 0.76 | 59.26 | 57.14 | > 90% |
| mNY criteria | 0.71 | 0.71 | 44.83 | 43.33 | — not stated in the abstract |
AUROC (first MRI reference standard)
Unequivocal sacroiliitis criteria0.76
mNY criteria0.71
AUROC (second MRI reference standard)
Unequivocal sacroiliitis criteria0.76
mNY criteria0.71
Sensitivity (first MRI reference standard)
Unequivocal sacroiliitis criteria59.26
mNY criteria44.83
Sensitivity (second MRI reference standard)
Unequivocal sacroiliitis criteria57.14
mNY criteria43.33
Specificity (both MRI reference standards)
Unequivocal sacroiliitis criteria> 90%
mNY criteria— not stated in the abstract
— not stated in the abstract
Further findings
| Outcome | Unequivocal sacroiliitis criteria | mNY criteria |
|---|---|---|
| Interrater agreement (Fleiss κ), fair | 0.58 (95% CI 0.46–0.69) | 0.54 (95% CI 0.42–0.67) |
Original publication
Consensus-Driven Definition for Unequivocal Sacroiliitis on Radiographs in Juvenile Spondyloarthritis. J Rheumatol. Published 15 April 2023. doi:10.
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