Sjögren's disease & overlap diseases
Comparison between primary Sjögren’s disease patients with high or low level of dryness
Authors' conclusion
Among the patients with SjD, those without high subjective or objective dryness features had a younger profile, a faster diagnosis which may result from a more acute onset, were more frequently anti-SSA positive than patients with high dryness features.
Study context
- Population
- Patients diagnosed with Sjögren's disease (SjD) according to AECG or ACR/EULAR criteria in a tertiary reference centre509 (subjective) and 472 (objective) compared
- Participants
- 456 / 53 / 359 / 113
- Exposure
- SjD patients with low vs high subjective dryness, and without vs with high objective dryness
- High subjective drynessn = 456reference
- Low subjective drynessn = 53
- High objective drynessn = 359reference
- Without high objective drynessn = 113
- Outcome
- Characteristics by subjective dryness level
Methodological detailssingle-centre, tertiary reference centre
- Single-centre
- Tertiary reference centre
Main finding
As reported in the abstract
- Low subjective dryness
- Age, median (IQR), years 49 (39-62) vs 58 (47-67) years; P < 0.01
- Low subjective dryness
- Median time from first symptoms to diagnosis 2 (0.5-4.5) vs 4 (1-9.25) years; P = 0.0056
- Low subjective dryness
- Anti-SSA positive 83% vs 64%; P = 0.008
- Low subjective dryness
- Focal sialadenitis in minor salivary gland biopsy 69% vs 83%; P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| Characteristics by objective dryness levelWithout high objective dryness vs High objective dryness | Age, years 51 (41-60) vs 58 (47-67) years | P < 0.001 |
| Characteristics by objective dryness levelWithout high objective dryness vs High objective dryness | Anti-SSA positive 79% vs 63% | P = 0.002 |
Characteristics by objective dryness level
- No difference regarding disease activity
Original publication
Comparison between primary Sjögren’s disease patients with high or low level of dryness. RMD Open. Published 29 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →