Autoinflammatory & rare systemic diseases
Comparative evaluation of disease activity measures for adult-onset Still’s disease: a multicentre, retrospective, cohort study
Authors' conclusion
mDAVID and mSDAS demonstrated the most favourable and largely comparable performance profiles across the evaluated metrics, with mDAVID showing greater responsiveness and mSDAS demonstrating a stronger correlation with the articular disease domain.
Study context
- Population
- Patients with initially active adult-onset Still's disease (AOSD) in an independent multicentre cohort (64% female; mean age 39.4±15.0 years)
- Participants
- 86 patients
- Exposure
- mDAVID vs mSDAS vs Still Activity Score (SAS) vs Pouchot's Systemic Score (PSS) as AOSD activity measures
- Outcome
- Criterion validity, AUC vs physician-determined disease activity
Methodological detailsmulticentre, imputed data primary analysis, complete-case sensitivity analysis
- Multicentre
- Imputed data primary analysis
- Complete-case sensitivity analysis
Main finding
As reported in the abstract
| Group | AUC |
|---|---|
| mDAVID | 0.68 |
| mSDAS | 0.69 |
| SAS | 0.68 |
| PSS | 0.60 |
AUC
mDAVID0.68
mSDAS0.69
SAS0.68
PSS0.60
Observational data: associations, not effects.
Further findings
| Outcome | mDAVID | mSDAS | SAS | PSS |
|---|---|---|---|---|
| Responsiveness, Cohen's d (95% CI) | 0.76 (95% CI 0.30–1.20) | 0.61 (CI 0.13–1.1) | 0.46 (CI −0.01–0.90) | 0.22 (CI −0.30–0.68) |
| Longitudinal sensitivity to change, marginal R² (95% CI) | 0.65 (95% CI 0.59–0.70) | 0.61 (CI 0.55–0.67) | 0.55 (CI 0.45–0.64) | 0.61 (CI 0.54–0.67) |
Complete-case sensitivity analyses
- Similar results to primary (imputed) analysis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparative evaluation of disease activity measures for adult-onset Still’s disease: a multicentre, retrospective, cohort study. RMD Open. Published 4 September 2026. doi:10.
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