Autoinflammatory & rare systemic diseases
Elevated monocyte distribution width in patients with active adult-onset Still's disease: a novel activity indicator
Authors' conclusion
Elevated MDW and its positive correlation with inflammatory parameters in AOSD patients indicate MDW as a novel activity indicator, with a high MDW value above 21.7 linked to a high probability of active AOSD.
Study context
- Population
- Patients with adult-onset Still's disease (AOSD) and patients with COVID-19 as disease control58 AOSD, 95 COVID-19
- Exposure
- Active AOSD vs inactive AOSD vs non-severe COVID-19
- Outcome
- Associations between MDW and disease activity or inflammatory parameters in AOSD
Methodological detailsdisease control (COVID-19), longitudinal follow-up
- Disease control (COVID-19)
- Longitudinal follow-up
Main finding
As reported in the abstract
Active AOSD
28.3
median · IQR 23.3–32.1
Inactive AOSD
19.2
IQR 18.0–20.6
Non-severe COVID-19
23.2
IQR 21.0–25.2
Active AOSD vs Inactive AOSD: P < 0.001 · Active AOSD vs Non-severe COVID-19: P < 0.01
Observational data: associations, not effects.
Further findings
| Outcome | Values |
|---|---|
| MDW threshold 21.7 to predict active AOSD | MDW >21.7 sensitivity 91.3% · specificity 94.3% |
Median monocyte distribution width (MDW) on longitudinal follow-up in AOSD
- Median MDW declined 28.3 vs 18.5 along with disease activity, paralleling decrease in C-reactive protein (CRP) and ferritin
- P < 0.001
MDW in severe COVID-19 and sepsis
- Elevated MDW, not different from active AOSD
MDW threshold 21.7 to predict active AOSD
- MDW a significant predictor of active AOSD in multivariate analysis
Original publication
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