Autoinflammatory & rare systemic diseases
Potential impact of autoimmune diseases family history in IgG4-related disease: a retrospective cohort study
Authors' conclusion
14.8% of IgG4-RD patients had AID family history, with younger age of disease onset age and higher frequency of ANA positivity in AID-positive group, indicating that IgG4-RD may share genetic background with other AID.
Study context
- Population
- Patients with IgG4-related Disease (IgG4-RD), Peking Union Medical College Hospital, China
- Participants
- 628 patients
- Exposure
- IgG4-RD with autoimmune diseases (AID) family history vs without AID family history
- AID-positiven = 93
- Outcome
- Prevalence of AID family history and its correlation with IgG4-RD features
Methodological detailssingle-centre, Cox regression
- Single-centre
- Cox regression
Main finding
As reported in the abstract
AID family history
AID-positive
14.8%
93
Observational data: associations, not effects.
Further findings
ANA positivity · baseline
P = 0.0277*
Riedel thyroiditis · baseline
P = 0.001*
Comorbid other AID · baseline
P = 0.0238*
Risk of unfavourable prognosis in AID-positive IgG4-RD (Cox analysis)
| HR (95% CI) | P value | ||
|---|---|---|---|
| Younger age | 0.97 (0.94–0.99) | P = 0.0384* | |
| Higher baseline peripheral eosinophils | 1.1 (1.02–1.2) | P = 0.0199* | |
| 0.512Hazard ratio (log scale) |
| Outcome | AID-positive | AID-negative | P value |
|---|---|---|---|
| Age of IgG4-RD onset · baselineEarlier onset in AID-positive | 50.4 ± 14.8 | 54.2 ± 12.6 | P = 0.014* |
Original publication
Potential impact of autoimmune diseases family history in IgG4-related disease: a retrospective cohort study. RMD Open. Published 9 February 2023. doi:10.
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