Autoinflammatory & rare systemic diseases
Factors associated with early clinical remission in patients with idiopathic retroperitoneal fibrosis
Authors' conclusion
Male gender and higher baseline C3 levels may act as potential predictors for achieving early remission in patients with IRF.
Study context
- Population
- Patients with idiopathic retroperitoneal fibrosis (IRF) at Peking Union Medical College Hospital, May 2013–December 2023
- Participants
- 91 patients
- Outcome
- Early clinical remission (≤6 months after treatment initiation)
- Follow-up
- 6 months
Methodological detailssingle-centre, multivariable analysis, nomogram model
- Single-centre
- Multivariable analysis
- Nomogram model
Main finding
As reported in the abstract
Factors associated with early clinical remission (≤6 months), multivariable analysis
Remission within 6 months of treatment initiation
38
Male gender, OR (95% CI 1.445-19.420), P=0.012
5.297
Higher baseline C3, OR (95% CI 1.131-4.097), P=0.019
2.153
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Time to remission by C3 levelHigh C3 (≥1.144 g/l) vs Low C3 (<1.144 g/l) · high C3 tended to achieve remission in a shorter time | P = 0.028 |
Correlation of time to remission with C3 levels
- R, P=0.014
- −0.243
Nomogram (gender and C3) predicting remission
- AUC
- 0.73 (95% CI 0.62-0.84)
Original publication
Factors associated with early clinical remission in patients with idiopathic retroperitoneal fibrosis. Rheumatology (Oxford). Published 17 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →