Autoinflammatory & rare systemic diseases
Derivation and validation of adult Still Activity Score (SAS)
Authors' conclusion
SAS has shown a good test performance to distinguish active AOSD patients from others.
Study context
- Population
- Consecutive Adult-onset Still's disease (AOSD) patients fulfilling Yamaguchi criteria
- Participants
- 197 consecutive AOSD patients
- Exposure
- Derivation vs Validation
- Derivationn = 125
- Validationn = 72
- Outcome
- Performance of SAS to discriminate high AOSD activity from moderate-inactive AOSD (AUC)
Methodological detailsmulticenter, derivation and validation cohorts, ordinal logistic regression
- Multicenter
- Derivation and validation cohorts
- Ordinal logistic regression
Main finding
As reported in the abstract
SAS discrimination of high vs moderate-inactive AOSD activity (AUC)
| Group | AUC |
|---|---|
| Derivation | 0.98 (0.96-1.00) |
| Validation | 0.91 (95%CI: 0.85-0.98) |
AUC
Derivation0.98 (0.96-1.00)
Validation0.91 (95%CI: 0.85-0.98)
Observational data: associations, not effects.
Further findings
Correlation of SAS with PGA
Original publication
Derivation and validation of adult Still Activity Score (SAS). Joint Bone Spine. Published 21 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →