Autoinflammatory & rare systemic diseases
Persistent Interleukin‐18 Fuels Expansion of CD38 + HLA ‐ DR + CD8 + T Cells in Still Disease and Macrophage Activation Syndrome
Authors' conclusion
CD38+HLA-DR+CD8+ cells, previously primarily associated with MAS, are detectable early in SD. Persistent IL-18 exposure promotes their expansion.
Study context
- Population
- Patients with Still disease across disease stages, including macrophage activation syndrome (MAS)
- Comparison
- CD38+HLA-DR+CD8+ T cells across SD stages vs healthy donors
- SD onsetn = 19
- Inactive diseasen = 15
- MASn = 12
- Outcome
- Frequency of CD38+HLA-DR+CD8+ T cells across disease stages
Methodological detailslongitudinal, spectral flow cytometry, bulk RNA sequencing, in vitro cytokine stimulation
- Longitudinal
- Spectral flow cytometry
- Bulk RNA sequencing
- In vitro cytokine stimulation
Main finding
As reported in the abstract
CD38+HLA-DR+CD8+ T cell frequency
Original publication
Persistent Interleukin‐18 Fuels Expansion of CD38 + HLA ‐ DR + CD8 + T Cells in Still Disease and Macrophage Activation Syndrome. Arthritis Rheumatol. Published 1 September 2026. doi:10.
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