The coexistence of diabetes, hypertension and obesity is associated with worse pain outcomes following exercise for osteoarthritis: A cohort study on 80,893 patients
Authors' conclusion
When diabetes, hypertension and obesity coexist with OA, patients not only experience heightened baseline pain compared to metabolically healthy individuals, but the disparity increases after an education and exercise intervention
Study context
- Population
- People with knee or hip osteoarthritis (OA) in the Swedish Osteoarthritis Register who underwent education and exerciseknee or hip OA
- Participants
- 80,893 people
- Exposure
- Coexisting obesity, hypertension and diabetes vs none of the conditions
- Outcome
- Pain (NRS 0-10) following education and exercise
Methodological detailslinear mixed-effect models with patients nested into clinics, adjusted for age, sex, education and physical activity
- Linear mixed-effect models with patients nested into clinics
- Adjusted for age, sex, education and physical activity
Main finding
As reported in the abstract
Pain (NRS 0-10), knee OA, adjusted mean pain difference
Obesity + hypertension + diabetes vs None of the conditionsAdjusted mean pain difference (95 % CI)
Baseline
0.9(0.8–1.0)
3 months
1.0(0.9–1.1)
12 months
1.3(1.1–1.4)
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted mean pain difference (95 % CI) | |
|---|---|---|
| Pain (NRS 0-10), hip OA, adjusted mean pain differenceObesity + hypertension + diabetesvs None of the conditionsBaseline | 0.7 (0.5–0.8) | |
| Pain (NRS 0-10), hip OA, adjusted mean pain differenceObesity + hypertension + diabetesvs None of the conditions3 months | 0.8 (0.6–1.0) | |
| Pain (NRS 0-10), hip OA, adjusted mean pain differenceObesity + hypertension + diabetesvs None of the conditions12 months | 1.1 (0.8–1.3) | |
| −1012Difference (linear scale) |
Original publication
The coexistence of diabetes, hypertension and obesity is associated with worse pain outcomes following exercise for osteoarthritis: A cohort study on 80,893 patients. Osteoarthritis Cartilage. Published 29 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →