Impact of an intervention for osteoarthritis based on exercise and education on metabolic health: a register-based study using the SOAD cohort
Authors' conclusion
An OA exercise and education intervention designed following OA clinical practice guidelines led to small and unlikely clinically relevant improvements in metabolic health markers in individuals with OA and diabetes.
Study context
- Population
- Individuals with osteoarthritis (OA) and diabetes, Swedish Osteoarthritis and Diabetes cohort (Swedish Osteoarthritis Register (SOAR) and National Diabetes Register); mean age 69.5 (SD 7.8), 52.7% women, 71.2% knee OAmatched cohort
- Participants
- 4,571 vs 7,925
- Exposure
- 6-week OA exercise and education intervention vs matched controls with diabetes who did not undergo it
- Interventionn = 4,571
- Controlsn = 7,925reference
- Outcome
- Metabolic health markers: BP, HbA1c, HDL, total cholesterol and weight
- Follow-up
- Up to 3 years before and after SOAR enrolment
Methodological detailsmatched on birth year, sex, OA site (hip/knee) and OA diagnosis year, two-way fixed-effect models
- Matched on birth year, sex, OA site (hip/knee) and OA diagnosis year
- Two-way fixed-effect models
Main finding
As reported in the abstract
Metabolic health markers
Systolic blood pressure (BP) decrease vs control, at 6 and 12 months (approximately)
1.0 mm Hg
High-density lipoprotein (HDL) increase at 12, 18 and 24 months (about)
0.02 mmol/L
Weight decrease at 6, 18 and 30 months (approximately)
0.5 kg
HbA1c increase at 6 months (approximately)
0.5 mmol/mol
Observational data: associations, not effects.
Original publication
Impact of an intervention for osteoarthritis based on exercise and education on metabolic health: a register-based study using the SOAD cohort. RMD Open. Published 26 February 2025. doi:10.
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