Vasculitis & polymyalgia rheumatica
Clinical implications of peripheral eosinophil count at diagnosis in patients newly diagnosed with microscopic polyangiitis and granulomatosis with polyangiitis
Authors' conclusion
This study was the first to demonstrate that peripheral eosinophil count at diagnosis could estimate cross-sectional AAV activity at diagnosis and contribute to predicting all-cause mortality during follow-up in MPA and GPA patients.
Study context
- Population
- Immunosuppressive drug-naïve patients newly diagnosed with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA), peripheral eosinophil count at diagnosis < 1,000/mm³ (median age 62.0 years; 35.3% men)152 MPA and 72 GPA
- Participants
- 224 patients
- Exposure
- Peripheral eosinophil count at diagnosis ≥ 175.0/mm³ vs < 175.0/mm³
- Outcome
- Cross-sectional antibody-associated vasculitis (AAV) activity at diagnosis and all-cause mortality during follow-up
Main finding
As reported in the abstract
- Eosinophil count significantly correlated with Birmingham Vasculitis Activity Score (BVAS)
- P = 0.001
- Eosinophil count significantly correlated with Five-Factor Score (FFS)
- P = 0.046
- Eosinophil count significantly correlated with erythrocyte sedimentation rate (ESR)
- P < 0.001
- Eosinophil count significantly correlated with C-reactive protein (CRP)
- P < 0.001
- Deceased vs surviving patients: median eosinophil count at diagnosis 310.0/mm³ vs. 170.0/mm³ (significantly higher in deceased)
- P = 0.004
- Eosinophil count ≥ 175.0/mm³ (optimal cut-off for all-cause mortality): significantly lower cumulative survival than < 175.0/mm³
- P = 0.008
Observational data: associations, not effects.
Further findings
Peripheral eosinophil count by disease and manifestations · at diagnosis
- Patients with MPA and those with cardiovascular and renal manifestations had significantly higher eosinophil counts than those without
Original publication
Clinical implications of peripheral eosinophil count at diagnosis in patients newly diagnosed with microscopic polyangiitis and granulomatosis with polyangiitis. Arthritis Res Ther. Published 15 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →