Vasculitis & polymyalgia rheumatica
Soluble Tyro-3 and Axl may reflect the current activity and the renal involvement in patients with microscopic polyangiitis and granulomatosis with polyangiitis
Authors' conclusion
This study demonstrated the potential of the serum concentrations of sTyro-3 and sAxl to reflect the current activity and renal involvement in patients with MPA and GPA.
Study context
- Population
- Patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA); median age 66.0 years, 43.4% men
- Participants
- 76 patients
- Exposure
- MPA vs GPA
- MPAn = 47
- GPAn = 29
- Outcome
- Correlation of serum sTyro-3, sAxl and sMer with current AAV activity (BVAS)
- Follow-up
- AAV diagnosis
Methodological detailsstored serum at AAV diagnosis
- Stored serum at AAV diagnosis
Main finding
As reported in the abstract
Independent correlation with BVAS
sTyro-3 independently correlated with BVAS (β)
0.343
sAxl independently correlated with BVAS (β)
0.310
Observational data: associations, not effects.
Further findings
Renal involvement of MPA and GPA
- sTyro-3 independently associated with renal involvement (OR)
- 1.003
- sAxl independently associated with renal involvement (OR)
- 1.055
Original publication
Soluble Tyro-3 and Axl may reflect the current activity and the renal involvement in patients with microscopic polyangiitis and granulomatosis with polyangiitis. Clin Exp Rheumatol. Published 11 December 2022. doi:10.
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