Vasculitis & polymyalgia rheumatica
First-year cumulative myeloperoxidase-ANCA titres are associated with all-cause mortality in patients with microscopic polyangiitis
Main finding · All-cause mortality during follow-up in MPAResult — go to the resultRelative risk 13.250Authors' conclusion
This is the first study to demonstrate the association between first-year cumulative MPO-ANCA titres and all-cause mortality during follow-up in patients with MPA.
Study context
- Population
- Patients with microscopic polyangiitis (MPA) and GPA74 MPA, 40 GPA
- Exposure
- MPA patients with first-year cumulative MPO-ANCA titres ≥720.8 IU/mL vs those without
- Outcome
- All-cause mortality during follow-up
Main finding
All-cause mortality during follow-up in MPA
Relative risk
13.250
As reported in the abstract
- Optimal cut-off for all-cause mortality (ROC analysis)
- 720.8 IU/mL
Observational data: associations, not effects.
Further findings
Cumulative patients' survival rate in MPA
- Significantly lower in MPO-ANCA ≥720.8 IU/mL than those without
Antineutrophil cytoplasmic antibody (ANCA) titres at diagnosis vs concurrent MPA and GPA activity or inflammatory burden
- No significant correlation
Original publication
First-year cumulative myeloperoxidase-ANCA titres are associated with all-cause mortality in patients with microscopic polyangiitis. Clin Exp Rheumatol. Published 14 December 2023. doi:10.
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