Lupus & antiphospholipid syndrome
Choroidal thickness in active lupus nephritis
Authors' conclusion
The observed thinning of central subfoveal CT in patients with active LN prior to treatment suggests that the choroid may serve as a subclinical target organ affected by systemic inflammation.
Study context
- Population
- Patients with active lupus nephritis (LN) (2019 ACR/EULAR SLE criteria) prior to induction treatment; biopsy-confirmed LN in 20
- Comparison
- Active LN before induction treatment vs healthy controls
- LNn = 28
- Outcome
- Central subfoveal choroidal thickness (enhanced depth imaging spectral-domain optical coherence tomography)
Methodological detailsconsecutive patients, controls balanced by sex and age
- Consecutive patients
- Controls balanced by sex and age
Main finding
As reported in the abstract
Central subfoveal choroidal thickness, mean
P = 0.004
Observational data: associations, not effects.
Further findings
Histological class (biopsy-confirmed LN)
- Predominantly proliferative
- 14/20 (70%)
Renal parameters
- Median creatinine
- 0.80 ± 0.26 mg/dL
- Elevated median protein/creatinine ratio
- 1.84 ± 1.70 g/g
Original publication
Choroidal thickness in active lupus nephritis. Lupus. Published 9 January 2026. doi:10.
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