Lupus & antiphospholipid syndrome
Renal efficacy of calcineurin inhibitors in treatment-resistant lupus nephritis: An experience among Mexican patients from a tertiary referral center
Authors' conclusion
For a Mexican cohort of patients with treatment-resistant lupus nephritis, the addition of CNIs can be effective. It achieves excellent biochemical response rates despite a transient reduction in eGFR that improves without treatment withdrawal.
Study context
- Population
- Mexican patients with SLE and lupus nephritis (LN) with persistent proteinuria despite previous immunosuppression who began a combined regimen including Calcineurin Inhibitors (CNIs)239 records evaluated
- Participants
- 42 patients
- Exposure
- CNI-containing combined regimen, 12 months vs baseline
- Outcome
- 24-hour proteinuria and eGFR (CKD-EPI), stratified by LN histological class
- Follow-up
- 12 months
Methodological detailssingle-centre, tertiary referral center
- Single-centre
- Tertiary referral center
Main finding
As reported in the abstract
Renal response
Complete response
26.2%
Partial response
35.7%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| eGFR, baseline vs 6 months (transient decrease)109 vs 104 mL/min/1.73 m² (baseline vs 6 months) | P = 0.001 |
| eGFR, baseline vs 12 months109 vs 114 mL/min/1.73 m² (baseline vs 12 months) | P = 0.023 |
- 24-hour proteinuria, baseline vs 12 months — Significant reduction in proteinuria vs baseline · 2.89 vs 0.72 g/d (baseline vs 12 months)
- 2.89 vs 0.72 g/d · P < 0.001
Original publication
Renal efficacy of calcineurin inhibitors in treatment-resistant lupus nephritis: An experience among Mexican patients from a tertiary referral center. Lupus. Published 8 January 2026. doi:10.
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