Lupus & antiphospholipid syndrome
Long-term trends of mortality from systemic lupus erythematosus in England & Wales and the United States
Authors' conclusion
The similarities in the birth-cohort patterns of SLE and other EBV-associated diagnoses suggest that they all share a common risk factor, such as EBV infection.
Study context
- Population
- Vital Statistics of England & Wales and the United States from 1951 to 2022
- Exposure
- Mortality trends of systemic lupus erythematous (SLE) vs those of Hodgkin lymphoma, multiple sclerosis, Crohn's disease and ulcerative colitis
- Outcome
- Mortality trends of SLE (birth-cohort pattern)
Methodological detailsbirth-cohort analysis of vital statistics, 1951 to 2022
- Birth-cohort analysis of vital statistics, 1951 to 2022
Main finding
As reported in the abstract
SLE mortality, birth-cohort pattern
- Mortality from SLE rose among generations born during the 19th century and decreased among generations born subsequently during the 20th century
- Birth-cohort pattern of SLE matched by almost identical patterns for multiple sclerosis (MS) and Crohn's disease (CD)
- Hodgkin lymphoma (HL) and ulcerative colitis (UC): similar rise-and-fall birth-cohort patterns, shifted by 10-20 years towards earlier generations vs SLE, MS and CD
Observational data: associations, not effects.
Original publication
Long-term trends of mortality from systemic lupus erythematosus in England & Wales and the United States. Lupus. Published 7 January 2026. doi:10.
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