A study of calcineurin inhibitors in comparison with intravenous cyclophosphamide for initial induction treatment of lupus nephritis class Ⅲ, Ⅳ, V in Chinese children
Authors' conclusion
This study demonstrates that CNIs are safer and more effective than CYC for quickly reducing proteinuria and achieving higher CR rate in initial induction treatment for lupus nephritis class III/IV/V.
Study context
- Population
- Chinese children with LN class Ⅲ/Ⅳ/V treated initially with IV CYC or calcineurin inhibitors (CNIs), January 2009 to January 2022
- Participants
- 75 children
- Exposure
- Oral CNIs vs IV CYC, each with corticosteroids, as initial induction
- CNIn = 29
- CYCn = 46reference
- Outcome
- Complete remission (CR) rate
- Follow-up
- 3 months
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
CR rate · 6 months
Proteinuria reduction · 3 months
- Reduction of proteinuria more significant with CNI than CYC
Risk factors for non-remission after 6-month induction (multiple logistic regression)
- Edema, anti-dsDNA and CYC identified as risk factors
Safety
Overall incidence of adverse effects
P = 0.032
Original publication
A study of calcineurin inhibitors in comparison with intravenous cyclophosphamide for initial induction treatment of lupus nephritis class Ⅲ, Ⅳ, V in Chinese children. Lupus. Published 18 June 2025. doi:10.
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