Lupus & antiphospholipid syndrome
Evaluation of clinical, histological and biomarker response after initial therapy of lupus nephritis
Authors' conclusion
Discordance between clinical and histological response was confirmed, more patients achieved clinical response than histological response and, even in patients with histological response, not everyone presented clinical response.
Study context
- Population
- Patients with biopsy-confirmed lupus nephritis (LN) undergoing induction therapymean age 32.5±8.2 years
- Participants
- 24 patients
- Outcome
- Histopathological renal response in re-biopsy after induction therapy, correlated with the Target Renal Response (TRR)
- Follow-up
- After induction therapy
Methodological detailsopen, longitudinal, multicentre, repeat renal biopsy (T1 and T2)
- Open
- Longitudinal
- Multicentre
- Repeat renal biopsy (T1 and T2)
Main finding
As reported in the abstract
Clinical (TRR) vs histological response after induction therapy
- Achieved Target Renal Response (TRR)
- 18
- Did not reach TRR (3 failed proteinuria criterion, 2 creatinine, 1 both)
- 6
- Histological response
- 14
- Histological response without TRR
- 4
- Discordances between clinical and histological responses
- 12
- TRR without histological response
- 8
Observational data: associations, not effects.
Secondary outcomes
- Serum NGAL and serum KIM-1 correlated with urea and creatinine
- Higher urinary TWEAK in patients with persistent abnormal haematuria at T2
- No correlation of new biomarkers with activity score or histological class
Original publication
Evaluation of clinical, histological and biomarker response after initial therapy of lupus nephritis. Lupus Sci Med. Published 27 April 2026. doi:10.
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