Lupus & antiphospholipid syndrome
Cancer occurrence after SLE: effects of medication-related factors, disease-related factors and survival from an observational study
Authors' conclusion
High dosage of CYC and disease-related factors (low SLEDAI-2K, less mucocutaneous and haematologic involvement) were related factors for cancer occurrence after SLE, while no survival difference was observed.
Study context
- Population
- Patients with SLE at Peking Union Medical College Hospital, January 2006 to September 2017
- Participants
- 45 vs 128
- Comparison
- SLE patients with cancer after SLE vs matched SLE controls
- SLE-CAn = 45
- Controlsn = 128reference
- Outcome
- Risk factors for cancer occurrence after SLE
Methodological detailsmatched controls, single-centre, multivariable logistic regression
- Matched controls
- Single-centre
- Multivariable logistic regression
Main finding
As reported in the abstract
Risk factors for cancer occurrence after SLE (multivariable analysis)
Odds ratio (95% CI)P value
High dosage of CYC
1.027(1.008–1.046)
P = 0.005Low SLEDAI-2K at cancer diagnosis
0.756(0.579–0.986)
P = 0.039Mucocutaneous involvementnegatively associated
0.330(0.110–0.991)
P = 0.048Haematologic involvementnegatively associated
0.304(0.103–0.902)
P = 0.032Observational data: associations, not effects.
Further findings
| Outcome | SLE-CA | P value |
|---|---|---|
| Survival · 5 and 10 yearsNo significant difference; log-rank test | P = 0.177 | |
| 5-year survival | 95.2% | |
| 10-year survival | 92.1% |
Disease characteristics
- SLE-CA: higher cumulative CYC dosage, less mucocutaneous and haematologic involvement, higher anti-dsDNA positivity
- At cancer diagnosis, SLE-CA had lower SLEDAI-2K, tended to achieve DORIS remission and minimal disease activity, but had higher SLICC/ACR DI
Original publication
Cancer occurrence after SLE: effects of medication-related factors, disease-related factors and survival from an observational study. Rheumatology (Oxford). Published 28 May 2022. doi:10.
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