Lupus & antiphospholipid syndrome
SERPINA1 and plasminogen as novel biomarkers in obstetric antiphospholipid syndrome patients
Authors' conclusion
The complement and coagulation pathway and related DEPs (SERPINA1 and plasminogen) were of crucial importance in OAPS patients.
Study context
- Population
- Pregnancy patients at the late stage of pregnancy from the Chinese Rheumatism Data Center database (CRDC)from 212 follow-up pregnancy patients
- Participants
- 30 patients
- Comparison
- Obstetric antiphospholipid syndrome (OAPS) vs healthy controls
- OAPSn = 7
- SAPSn = 4
- SLEn = 8
- Healthy controlsn = 11reference
- Outcome
- Placental DEPs, OAPS vs healthy
Methodological detailsplacental proteomics, 4D label-free, bioinformatic analysis
- Placental proteomics
- 4D label-free
- Bioinformatic analysis
Main finding
As reported in the abstract
Proteins identified (≥1 unique peptide)
7040
Differentially expressed proteins (DEPs) between healthy and OAPS (fold change ≥1.5, p ≤0.05)
214
Upregulated in OAPS
82
Downregulated in OAPS
132
Original publication
SERPINA1 and plasminogen as novel biomarkers in obstetric antiphospholipid syndrome patients. Clin Exp Rheumatol. Published 25 May 2022. doi:10.
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