Lupus & antiphospholipid syndrome
Early recognition of catastrophic antiphospholipid syndrome in patients with antiphospholipid syndrome based on a Chinese cohort study
Authors' conclusion
A predictive model of CAPS was developed with hypertension, anaemia, elevated LDH and proteinuria.
Study context
- Population
- Antiphospholipid Syndrome (APS) patients referred to Peking Union Medical College Hospital, May 2013 to October 202127 catastrophic antiphospholipid syndrome (CAPS)
- Participants
- 226 patients
- Exposure
- High-risk vs Low risk
- Outcome
- CAPS (predictive model for early recognition)
Methodological detailssingle-centre, binary logistic regression, prediction model development, internal validation
- Single-centre
- Binary logistic regression
- Prediction model development
- Internal validation
Main finding
As reported in the abstract
Odds ratio (95% CI)
Hypertension historyscore 1 point
5.091(1.119–23.147)
Anaemiascore 3 points
116.231(10.512–1285.142)
Elevated LDHscore 3 points
59.743(7.439–479.815)
Proteinuriascore 2 points
11.265(2.118–59.930)
- CAPS incidence
- 11.9%
- Sensitivity
- 0.963
- Specificity
- 0.886
- AUC
- 0.971
- Nagelkerke's R2
- 0.739
- Omnibus test (χ2 =109.231, df=4)
- P = 0.000
Observational data: associations, not effects.
Original publication
Early recognition of catastrophic antiphospholipid syndrome in patients with antiphospholipid syndrome based on a Chinese cohort study. Clin Exp Rheumatol. Published 5 May 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →