Systemic sclerosis & Raynaud's
Biological hallmarks of systemic sclerosis are present in the skin and serum of patients with Very Early Diagnosis of Systemic Sclerosis (VEDOSS)
Authors' conclusion
Despite not fulfilling classification criteria, VEDOSS patients show SSc-linked fibrosis and immunity dysregulation both within the tissue and sera, supporting a biological diagnosis of disease and a window of opportunity to detect the biological pathways amenable for preventive intervention.
Study context
- Population
- Patients with Very Early Diagnosis of SSc (VEDOSS) in the EUSTAR study36 with skin biopsies
- Participants
- 114 patients
- Comparison
- VEDOSS vs healthy controls
- VEDOSSn = 114
- Outcome
- Biological SSc activity in VEDOSS skin, fibroblasts and serum
Methodological detailsconsecutive patients, longitudinal follow-up
- Consecutive patients
- Longitudinal follow-up
Main finding
As reported in the abstract
- Skin biopsies: variable but overall increased collagen staining and skin thickness, increased perivascular infiltrate of CD45-positive cells and CXCL10 expression
- VEDOSS dermal fibroblasts: increased profibrotic gene expression and contractibility vs healthy controls (HC)
Further findings
| Outcome | VEDOSS | HC | P value |
|---|---|---|---|
| Serum CXCL10VEDOSS vs HC · mean, pg/ml | 75.90 (SD 107.80) | 39.90 (SD 26.27) | P = 0.02 |
| ELF scoreVEDOSS vs HC · reported as increased in VEDOSS vs HC | 8.19 (SD 0.78) | 8.55 (SD 0.79) | P = 0.04 |
| Progression to SSc (longitudinal) · median 27.5 (IQR 44.5) months | 14.9% | — not stated in the abstract |
— not stated in the abstract
- Progression to SSc (longitudinal) — Baseline serum CXCL10 higher in VEDOSS patients who progressed (2-fold increase)
- P = 0.0071
- Progression to SSc (longitudinal) — Baseline CXCL10 correlated with ELF score (R = 0.3096)
- P = 0.0065
Original publication
Biological hallmarks of systemic sclerosis are present in the skin and serum of patients with Very Early Diagnosis of Systemic Sclerosis (VEDOSS). Rheumatology (Oxford). Published 19 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →